Gene Mutations in Cancer
Explore how driver gene mutations reshape tumor morphology and affect patient survival. HistoAtlas links mutation status to computational histomics features across 33 TCGA cancer types and 11,000+ whole slide images.
Tumor Protein P53
Kirsten Rat Sarcoma Viral Oncogene Homolog
B-Raf Proto-Oncogene
Epidermal Growth Factor Receptor
Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha
Phosphatase and Tensin Homolog
Isocitrate Dehydrogenase 1
AT-Rich Interaction Domain 1A
Understanding Driver Gene Mutations
Driver mutations are genetic changes that directly contribute to cancer development and progression. Unlike passenger mutations (which occur randomly and do not confer growth advantages), driver mutations activate oncogenes or inactivate tumor suppressor genes, enabling uncontrolled cell proliferation.
HistoAtlas tracks 8 of the most clinically significant driver genes across 33 TCGA cancer types. For each gene, we compute mutation frequency, survival impact (Cox regression and Kaplan-Meier curves), morphological associations (how mutations change what tumors look like under the microscope), and mutation co-occurrence patterns.
How to Use These Pages
Click any gene above to see its pan-cancer overview, including mutation frequency across cancer types and a survival forest plot. From there, drill into specific gene-cancer combinations to explore survival curves, morphology differences, and co-occurring mutations.